For more than two centuries, vaccines been used to generate protective immunity against diseases. Vaccines generally contain attenuated viruses, inactivated viruses/toxins, or pathogenic subunits. Nucleic acid-based vaccines induce a cell-mediate immune response without the presence of adjuvants, thus providing an advantage over subunit vaccines; they are also incapable of infecting the host, so they are a safer alternative compared to attenuated versions. The Seeker is searching for formulation improvements with a focus on RNA replicon vaccines. 兩個多世紀以來，疫苗一直用于產生針對疾病的保護性免疫。疫苗通常含有減毒病毒，滅活病毒/毒素或致病亞單位。基于核酸的疫苗在不存在佐劑的情況下誘導細胞介導的免疫應答，因此提供優于亞單位疫苗的優勢; 它們也無法感染宿主，因此與減毒版相比，它們是更安全的替代品。搜索者正在尋找配方改進，重點是RNA復制子疫苗。 有興趣的投稿個人（或企業）請將稿件發送到: https://www.innocentive.com/ar/solution/9934123 如果遇到任何問題，請留言聯系